Coronavirus COVID-19: presentación clínica, diagnóstico y tratamiento
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Un nuevo coronavirus zoonótico, declarado como pandemia y nombrado como 2019 betacoronavirus novel (2019-nCoV o COVID-19) por la Organización Mundial de la Salud, ha sido identificado como el agente causante de la epidemia de neumonía viral originada en Wuhan, China, a finales del 2019. Su amplia propagación se debe en gran medida a las características patogénicas que permitenuna transmisibilidad eficiente de persona a persona mediante gotas respiratorias, o por el contacto con fluidos corporales; asociada además a la capacidad de contagio por parte de los pacientes asintomáticos. Su diagnóstico se realiza mediante reacción en cadena de polimerasa, en conjunto con la historia clínica exploración física completa, exámenes de laboratorio y gabinete, para poder clasificar y abordar el caso según su severidad. Actualmente, no se ha desarrollado un tratamiento farmacológico específico, eficaz y seguro; el manejo recomendado se basa en controlar la sintomatología y brindar confort al paciente. La prevención incluye precauciones estándar, por gotas y contacto; así como educación a la población para evitar su propagación
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Chen J. Pathogenicity and Transmissibility of 2019-nCoV-A Quick Overview and Comparison with Other Emerging Viruses. Microbes and Infection. 2020;2019–2021. DOI: https://doi.org/10.1016/j.micinf.2020.01.004
Cheng ZJ, Shan J. 2019 Novel Coronavirus: Where We are and What We Know. Infection. 2020. DOI: https://doi.org/10.20944/preprints202001.0381.v1
Chang D, Xu H, Rebaza A, Sharma L, Dela Cruz CS. Protecting health-care workers from subclinical coronavirus infection. The Lancet: Respiratory Medicine.2020;2600(20):2001468. DOI: https://doi.org/10.1016/S2213-2600(20)30066-7
Han W, Quan B, Guo Y, Zhang J, Feng G, Wu Q, et al. Letter to the editor:The course of clinical diagnosis and treatment of a case infected with coronavirus disease 2019. Journal of Medical Virology. 2020;1–2. DOI: https://doi.org/10.1002/jmv.25711
Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. The Lancet. 2020;395:15–8. DOI: https://doi.org/10.1016/S0140-6736(20)30185-9
Liu Y, Liao C, Chang C, Chou C-C, Lin Y-R. Correspondence: Multidrug-Resistant Tuberculosis. New England Journal of Medicine. 2020;4–6.
Yu F, Du L, Ojcius DM, Pan C, Jiang S. Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes and Infection. 2020;1–6. DOI: https://doi.org/10.1016/j.micinf.2020.01.003
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet . 2020;497–506. DOI: https://doi.org/10.1016/S0140-6736(20)30183-5
Jiang S, Shi Z-L. The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus. Virologica Sinica. 2020;12250:5–7. DOI: https://doi.org/10.1007/s12250-020-00206-5
Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First Case of 2019 Novel Coronavirus in the United States. New England Journal of Medicine . 2020;1–9. DOI: https://doi.org/10.1056/NEJMoa2001191
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine 2020;1–7. DOI: https://doi.org/10.1056/NEJMoa2001017
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;1–9. H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. The Lancet. 2020;395(10223):514–23. DOI: https://doi.org/10.1016/S0140-6736(20)30154-9
World Health Organization. Situation report - 53: Coronavirus disease 2019 (COVID-19) [Internet]. 2020. p. 1–10. Available from: https://www.who.int/docs/default-source/cor onaviruse/situation-reports/20200313-sitrep -53-covid-19.pdf?sfvrsn=adb3f72_2
Munster V, Koopmans M, Doremalen N, Van Riel D, Wit E. A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment. New England Journal of Medicine . 2020;1–3. DOI: https://doi.org/10.1056/NEJMp2000929
Zhang J, Zhout L, Wang W, Chen X. Correspondence: Therapeutic and triage strategies for 2019 novel coronavirus. The Lancet: Respiratory Medicine. 2020;2600(20):2019–20.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(10223):507–13. DOI: https://doi.org/10.1016/S0140-6736(20)30211-7
World Health Organization. Interim guidance: Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. [Internet]. 2020. p. 12. Available from: https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov .pdf
Phan T. Novel coronavirus: From discovery to clinical diagnostics. Infection, Genetics and Evolution. 2020;79:104211. Zhang L, Liu Y. Potential Interventions for Novel Coronavirus in China: A Systemic Panayiotakopoulos G, Sourvinos G, Tsiodras S. Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event. Infection, Genetics and Evolution. 2020;79:104212. DOI: https://doi.org/10.1016/j.meegid.2020.104212
Pongpirul WA, Pongpirul K, Ratnarathon AC, Prasithsirikul W. Correspondence: Journey of a Thai Taxi Driver and Novel Coronavirus. New England Journal of Medicine. 2020;1. DOI: https://doi.org/10.1056/NEJMc2001621
Bastola A, Sah R, Rodriguez-morales AJ, Lal BK, Jha R, Ojha HC, et al. Correspondence: coronavirus case in. The Lancet Infectious Diseases . 2020;3099(20):2019–20. Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV Infection from DOI: https://doi.org/10.1016/S1473-3099(20)30067-0
an Asymptomatic Contact in Germany. New England Journal of Medicine. 2020;2019–20.
Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine. 2020;1–9. Phan LT, Nguyen T V., Luong QC, Nguyen T V., Nguyen HT, Le HQ, et al. Importation and Human-to-Human Transmission of a
Novel Coronavirus in Vietnam. New England Journal of Medicine. 2020. The Lancet Journal. Emerging understandings of 2019-nCoV. The Lancet. 2020;395(10221):311. DOI: https://doi.org/10.1016/S0140-6736(20)30186-0
Hoehl S, Rabenau H, Berger A, Kortenbusch M, Cinatl J, Bokjova D. Correspondece:Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China. New England Journal of Medicine. 2020;1–3. DOI: https://doi.org/10.1056/NEJMc2001899
Lipsitch M, Phil D, Swerdlow DL, Finelli L. Perspective: Defining the Epidemiology of Covid-19 — Studies Needed. New England mJournal of Medicine. 2020;1–3. DOI: https://doi.org/10.1056/NEJMp2002125
Xu X, Yu C, Zhang L, Luo L, Liu J. Letter to editor: Imaging features of 2019 novel coronavirus pneumonia. European Journal of Nuclear Medicine and Molecular Imaging . 2020;1–2. DOI: https://doi.org/10.1007/s00259-020-04720-2
Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res . 2020;(January):2019–21. DOI: https://doi.org/10.1038/s41422-020-0282-0
Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19
associated pneumonia in clinical studies. Bioscience Trends. 2020;1–2.